Thực đơn
Cefdinir Tổng hợpAcyl hóa amin thứ 1 với 4-bromo-3-oxobutanoyl bromide (2) leads to the amide (3). The active methylene group in that product is then nitrosated with natri nitrit; the initial product spontaneously tautomerizes to afford the oxime (4). The bromoketone array in that intermediate constitutes a classical starting function for construction of thiazoles. Reaction of 4 with thiourea thus leads to formation of an aminothiazole moiety. Thus there is obtained the antibiotic cefdinir (5).
Thực đơn
Cefdinir Tổng hợpLiên quan
CefdinirTài liệu tham khảo
WikiPedia: Cefdinir http://www.astellas.com/en/corporate/news/detail/a... http://wenku.baidu.com/view/a2ef6330b90d6c85ec3ac6... http://www.chemspider.com/Chemical-Structure.52917... http://www.drugs.com/monograph/cefdinir.html http://www.drugs.com/mtm/cefdinir.html http://www.elsevierbi.com/publications/the-pink-sh... http://v3.espacenet.com/textdoc?DB=EPODOC&IDX=%7B%... http://www.globenewswire.com/newsarchive/mrx/pages... http://www.google.com/patents?vid=4559334 http://drugtopics.modernmedicine.com/drugtopics/da...